Chapter 254 Honey Trap?
Since Zhang Yang himself was a technical R&D personnel, he felt no pressure at all when discussing with Wei Tian, ​​Dr. Zhou and many team leaders. There were no rules and regulations as in ordinary executive meetings, so the efficiency was extremely high.

after an hour,
After intense discussion, the subsequent improvement plan for the combined treatment of “ibuclumab” + “allogeneic T cells” was determined.

First of all, let’s briefly talk about why the combined treatment of “ibukumab” + “allogeneic T cells” leads to the side effect of bone marrow failure.

In fact, “Ivacumab” itself is a surface antigen targeted drug.

Compared with common inhibitor/blocker targeted drugs such as “Gleevec” and “Tenofovir”, surface antigen targeted drugs directly recognize cancer cells and kill them. They have certain drug toxicity and will inevitably cause some side effects.

of course,

Through six or seven years of repeated experiments and thousands of animal experiments, Wei Tian, ​​Dr. Zhou and others have controlled these side effects to an extremely small probability;
It can be said that even if long-term use produces severe side effects, such as the probability of bone marrow failure, is extremely low.

What about the “allogeneic T cell” injection?

The “allogeneic T cell” injection is actually a relatively safe, mainstream immune preparation. If it were very dangerous, it would not have been able to pass regulation and be successfully marketed.

At present, it is mainly used in CAT-T cell therapy in clinical practice, or to put it bluntly, it is mainly used to treat some cancer patients.

The principle is roughly to inject “allogeneic T cells” into the body of cancer patients, or directly into tumor tissue. Through the appearance of “allogeneic T cells”, the patient’s immune system is activated to produce an emergency response, forcing the patient’s immune cells to start working, thereby achieving the effect of eliminating some cancer cells.

This method is also effective in treating cancer patients, and the side effects are not very obvious.

But the bad thing is that although the vast majority of cancer patients have cancer, they have not undergone organ transplants, so there is no long-term acute rejection in their bodies!
The vast majority of leukemia patients have already undergone bone marrow transplantation and have allogeneic bone marrow stem cells in their bodies, and some are even in chronic rejection reactions.

The emergence of “allogeneic T cells” will undoubtedly accelerate the speed of rejection reaction in leukemia patients, causing the immune system to frantically attack bone marrow stem cells that originally had normal hematopoietic function, and eventually cause failure.

In addition, as I just mentioned, “Ibetuzumab” itself has certain toxicity. Under multiple BUFFs, the side effects of the combined treatment plan are obviously several times beyond the normal range!
The plan that Dr. Zhou and others finally decided on is:
Since the purpose of injecting “allogeneic T cells” is to make the patient produce an acute rejection reaction, thereby increasing the metabolic rate of immune cells in the body.

So, is it possible to skip the acute rejection reaction and directly control the immune cell pathways through drugs to convey the instruction to speed up the metabolic rate?

In this way, the body’s immune system will not be activated, no acute rejection reaction will occur, and T cells will not attack transplanted bone marrow stem cells.

After the immune cells speed up their metabolism, they should also be able to produce a large amount of TEF glycoprotein, thereby enhancing the therapeutic effect of “ibuclumab”!

It can be said that this method bypasses the acute rejection reaction and achieves the goal directly. The only side effect is that the patient feels hungry faster.

But this is clearly not a side effect.

Zhang Yang was also looking forward to this preliminary plan. After he made some suggestions, one of the next focuses of the first project team was determined:

Find the target pathway that enables immune cells to increase their metabolic rate, and thus develop a drug to replace the current “allogeneic T cell” injection.

After doing all this, Zhang Yang finally returned to the office satisfied.

At this time, Ren Xiaomin had already left the office, and it was empty. Looking through the window at the city area with tall buildings not far away, Zhang Yang couldn’t help but let out a sigh of relief.

The biggest side effect of the combination therapy with “Ivacuzumab” has been solved by ITG myelopoietin, and the future improvement plan has also been determined. Next, with the current basic therapeutic effect of “Ivacuzumab” as high as 83%, it will not be difficult to successfully pass the clinical trial as long as there are no particularly serious side effects.

It can be said that the issue regarding “ibumazumab” has basically come to an end in a short period of time.

of course,

“Ivacumab” ultimately failed to completely cure acute myeloid leukemia, but its appearance can at least provide more leukemia patients with new options.

Especially those patients like Xia Xue whose disease relapsed after bone marrow transplantation, and those who have developed resistance to chemotherapy drugs and can only wait to die!
For them, Ibetumumab is their only hope!
Although “Ivacuzumab” cannot completely cure the leukemia cancer cells in their bodies, it can at least maintain a normal life cycle for a longer period of time.

Ten years, or even twenty years is possible!

As for the resistance to Ibelumab…

This is the top advantage of cell antigen targeted drugs. Since they use the violent method of directly killing antigens, it is not easy for immune escape and gene mutation to occur!

And once the patient persists for ten years…

Ten years later, has Qingshan Pharmaceutical still not developed a drug that can completely cure acute leukemia? !

Zhang Yang couldn’t help but smile. With more and more patient data and with more clinical applications of “ibukumab” in the future, he is confident that acute leukemia can be completely conquered within the next ten years.

“Come on, Zhang Yang!”

Thinking of this, Zhang Yang also felt a strong sense of accomplishment and mission in his heart.

But at this moment, there was a deep knock on the tightly closed office door. Zhang Yang was in a good mood and said with a smile:
“Please come in.”

Assistant Xiao Chen came in with a bouquet of flowers in his hand.

“Mr. Zhang, a runner just brought a bouquet of flowers over and specifically said it was for you.”

“Given to me?”

Zhang Yang was already in a good mood, and it had been a long time since he had received flowers from anyone, so he walked over quickly out of curiosity.

But as soon as he picked up the message card on the flowers, his expression suddenly became a little strange.

“She actually gave it to me?”

Xiao Chen naturally didn’t know who sent the flowers. After handing the flowers to Zhang Yang, he tactfully left the office.

As soon as the office door was closed, a crisp cell phone ringtone suddenly rang out.

Zhang Yang took out his cell phone and couldn’t help but smile when he saw the incoming call number in front of him.

It came quite quickly!

“Hello.”

A sweet yet elegant voice soon came from the other end of the phone.

“Hello, Mr. Zhang, I’m Minako, do you remember me?”

“Of course I remember, Miss Minako, what’s wrong?”

“Thank you for remembering me. I can finally put my mind at ease when I hear your relaxed tone… Mr. Zhang, I ordered a bouquet of flowers for you. Did you receive it?”

Zhang Yang lowered his head and sniffed the flowers in his hand, then said with a smile:
“Thank you. I got it.”

“But I don’t like white roses very much. I prefer sunflowers and orchids…”

“Ah! Is that so? Mr. Zhang, I’ll order a new bouquet for you then.”

“That’s no need.”

Hearing Minako on the other end of the phone panicking and wanting to order another bouquet of flowers for herself, Zhang Yang hurriedly stopped her:

“I just said it casually. Thank you for your flowers. I am still very satisfied.”

“That’s good.” Minako breathed a sigh of relief. After a moment, her sweet and elegant voice came from the phone again.

“Minako is really happy to be liked by you.”

“Yesterday I saw a lot of bad news about Qingshan Pharmaceutical on the Internet, and I was worried that you would be in a bad mood, so I specially sent you a bouquet of flowers. I hope you will smile happily after receiving it.”

“I didn’t expect that Minako still underestimated your carefreeness. I’m afraid this kind of thing is really not worth mentioning in your eyes!”

It has to be said that Zhang Yang is usually surrounded by straight men like Wei Tian, ​​Dr. Zhou, and Ren Xiaomin. Even Wei Tian only flatters him occasionally. Minako is unlike him who uses honorifics all the time and her words are full of concern and praise.

Zhang Yang knew that Minako was trying to please him and flatter him, but that didn’t stop him from hearing these words sound comfortable.

“Haha, not as free and easy as you say.”

“I also read some comments online, and was also angered by many netizens’ comments!”

“Like this?”

Minako’s tone was slightly surprised, and then she continued:

“In that case, Minako would like to invite you to dinner. Is that okay?”

“Dinner? Tonight?”

“Well, to be honest, after seeing the comments criticizing Qingshan Pharmaceutical and you on the Internet, I took a leave of absence and flew here from Shanghai. I’m almost downstairs at your company now!”

Zhang Yang was slightly stunned. He never expected that Minako not only gave him flowers, but also took the initiative to fly from Shanghai to Chengdu.

But he soon realized that Minako had chosen a good time.

Many netizens on the Internet are smearing Aoyama Pharmaceutical. Under normal circumstances, I would not be in a very good mood. Minako appeared at this time to comfort me, and my favorability must have increased greatly.

People are often strange animals. Even though Zhang Yang knew that Minako had a purpose in trying to please him, he couldn’t help but feel a little strange at this moment.

“Mr. Zhang, do you think this is ok?”

Having said that, Zhang Yang had no way to refuse.

“Well, I have nothing to do tonight, so let’s have dinner together.”

“That’s great. I’ll be at your company in five minutes… Can I come to your office?”

“OK.”

Minako was on time. Five minutes later, she walked into the office. She was tall and beautiful like a star.

“Mr. Zhang, it’s nice to see you again.”

“Please sit down, Miss Minako. You are more beautiful than last time.”

This was the second time Zhang Yang saw Minako, and he couldn’t help but look at her again.

Compared to the first time when she wore traditional work clothes, Minako’s clothes this time are obviously more fashionable. The off-shoulder slim dress outlines her graceful figure, and the irregular cutting design at the hem adds a bit of elegance and sexiness.

Paired with a pair of black thin-strap high heels, revealing a small section of white calves, she looks seductive and elegant, with a bit of a devil and angel feel.

“Thank you for the compliment. It seems that you like Minako to dress elegantly… Minako remembers!”

“…”

Zhang Yang couldn’t help but sigh in his heart. He had to admit, it felt really good to be praised by others.

Ten minutes later, he finished dealing with some urgent documents and saw that it was six o’clock in the afternoon, so he called Minako to leave.

“Let’s go, I’m done with my work, do you want anything to eat?”

“Mr. Zhang, I’ve agreed to treat you. I’ve picked a traditional Chinese restaurant. Their dishes are pretty good. Do you think it’s suitable?”

“OK.”

Zhang Yang didn’t hesitate, and soon the two drove to a traditional Chinese restaurant in the city center.

It was lunchtime and the hall was already crowded with people, with all seats occupied. It was obvious that business was booming.

The two of them came to the private room that they had booked in advance. After they sat down, Zhang Yang suddenly felt that the atmosphere in the room became a little charming.

Especially since Minako exuded a faint fragrance and her dress’s chest was vaguely visible, which made him feel a little distracted.

He coughed lightly and quickly diverted his attention:

“Minako, you said before that you are of Chinese and Japanese descent. Is your father Chinese or is your mother Chinese?”

Minako elegantly filled a cup of tea for Zhang Yang, smiled slightly, and replied:

“Mr. Zhang, my father is Chinese, my mother is Japanese, and I was born in Japan, so I am a Japanese citizen.”

“But my father brought me to China when I was ten years old and I lived in China for nearly ten years, so… I have some understanding of both Japanese and Chinese culture.”

“Oh.”

Zhang Yang nodded slightly:

“So how did you join Novartis?”

Speaking of Novartis, Minako couldn’t help but show a hint of pride on her face.

“I went to the United States to study when I was 18 years old. I received a master’s degree in molecular biology from the University of Pennsylvania, and then I was accepted by Novartis’ office.”

Zhang Yang was stunned. He didn’t expect that Minako in front of him was actually a master of biology from one of the Ivy League universities in the United States.

“You are amazing. It’s not easy to get a master’s degree in biology from the University of Pennsylvania.”

Hearing Zhang Yang’s praise, Minako smiled brightly:
“I am so far inferior to you! You are my idol!”

As she spoke, Minako picked up the teacup and walked in front of Zhang Yang, the distance between them was less than ten centimeters.

Zhang Yang could even clearly see the delicate pores on Minako’s fair neck, and her swollen breasts that were almost touching him.

“Mr. Zhang, let me toast you.”

Zhang Yang smiled slightly and did not refuse.

After a moment, he smiled and said:
“Ask the waiter to serve the food, and we can chat while we eat.”

(End of this chapter)