Chapter 295 Some Results

“Teacher, long time no see.”

He Youwei, who had been at the Hailufeng Hospital in the city these days, heard that Jiang Miao was coming and came out to greet him.

“Is your work going well recently?” Jiang Miao asked with a smile.

He Youwei led the way and replied, “Thank you for your concern, teacher. I am fine. Recently, our hospital has treated more than 3,000 lupus patients and has made long-term customized drug plans for these patients.”

“What about talent training?”

“I have currently recruited five doctoral students in related fields. With their help, my work has become much easier.”

“That’s good.”

Jiang Miao thought of the child with congenital heart disease in the village and asked casually, “By the way, Youwei, how is the child I arranged for treatment here now?”

“Child?” He Youwei was confused.

Dean Zhang Suqing at the side quickly replied: “Boss, are you talking about the patient with congenital heart disease?”

“Ah.”

“He is doing very well and was discharged from hospital at the beginning of this month.”

“How well is the new technology validated?”

Zhang Suqing immediately knew what Jiang Miao was asking, so he quickly organized the content in his mind, pushed his glasses and replied:

“Our hospital has performed 17 nano-needle surgeries so far, all of which were of a type that traditional surgery and minimally invasive surgery were not suitable for. Since they were experimental in nature, we did not charge any fees, but instead subsidized the patients with more than yuan in experimental subsidies. Together with other expenses, the total loss was nearly yuan.”

“It doesn’t matter.” Jiang Miao didn’t mean to blame.

After all, this is an attempt to try out new technology, and in order to accumulate sufficient clinical experience, patients must be subsidized in the early stages.

Zhang Suqing also mentioned another thing: “Boss, Professor He from Changan came to our hospital a few days ago for three days of communication. He is very optimistic about our nanoneedle technology and plans to communicate with us further.”

“Okay, but is Professor He just here to communicate?”

“He also came here to perform three brain tumor surgeries. The main reason was that the conditions of several patients were difficult. Our hospital did not have enough experience in this area, so we had to ask him to fly over.”

While they were talking, the group had already arrived at an office.

As soon as Jiang Miao sat down, Zhang Suqing took out a thick document: “Boss, these are the various clinical trials that our hospital has been conducting in the past six months.”

The Urban Hailufeng Hospital is the headquarters of the eight Hailufeng hospitals. It not only undertakes management work, but also serves as the technical verification center and talent training center of the Hailufeng Hospital.

A variety of new drugs, new medical technologies, and medical equipment are undergoing clinical trials here.

Jiang Miao opened the file and the first page was the directory.

【Clinical test report on the killing of tumor cells by Yulin protein (1)】

【Yulin protein…】

Followed by relevant clinical test reports on 8 types of Yulin proteins, targeting brain tumors, pancreatic cancer, breast cancer, liver cancer, lung cancer, bone cancer, laryngeal cancer, and colorectal cancer.

【Clinical test report of Antibacterial】

【Clinical test report of gene target therapy for lupus erythematosus】

【Clinical test report of nano-needle non-invasive surgery】

【Clinical test report of Kangfengling】

【Clinical test report of genetically modified rice human serum】

All in all, there are nearly twenty clinical test reports.

In order to conduct these clinical tests, the urban Hailufeng Hospital spent nearly 300 million yuan on clinical tests last year. If it were not for the support of the towering Hailufeng Company, it is estimated that not many public hospitals would have the strength to do so.

However, these expenditures are also very valuable, at least a huge amount of clinical data has been obtained.

Although they were all clinical tests, Hailufeng Hospital did not cause any medical accidents. After all, those new technologies and new drugs had undergone many animal experiments and simulation analyses, and basically no major problems would occur.

What’s more, Hailufeng Company provides a considerable subsidy to each patient who participates in the clinical trials. Many people are trying their best to save money, or simply have no money and plan to earn some money to supplement their family expenses by participating in clinical trials.

“Is this Kangfengling performing so well?” Jiang Miao was looking at the clinical test report on Kangfengling.

He Youwei is quite familiar with this drug. After all, this drug for treating gout will be produced by Xin Kangle Pharmaceutical, which she manages, in the future. Therefore, she is more concerned about these things:
“Yes, teacher. This new drug is a gene-targeted drug that targets specific genes. The laboratory has found a number of genes related to the mechanism of gout through analysis using the Nuwa system, and has developed several drugs. Currently, Kangfengling is one of the few drugs that can enter the human trial stage.”

Jiang Miao looked at the contents of the report and found that this new drug was indeed good.

The mechanism of action of Kangfengling is somewhat different from that of the current mainstream treatments for gout, including febuxostat, allopurinol, and benzbromarone.

Febuxostat and allopurinol inhibit the synthesis of uric acid in the body, thereby reducing the uric acid concentration in the body.

Benzbromarone achieves the purpose of treating gout by increasing excretion, accelerating the excretion of uric acid from the body.

The mechanism of action of Kangfengling is to restore the body’s ability to self-regulate uric acid. It targets five related gene targets and conducts comprehensive combined treatment to stimulate the body’s ability to self-regulate uric acid.

As long as you take it continuously for about 3 to 6 months, your body will recover on its own and you will not need to continue taking the medicine.

Of course, the drug is not without its drawbacks.

The first disadvantage is that this drug cannot be taken orally and can only be injected intravenously.

The second disadvantage is that the drug is only effective on East Asians, and its effect is relatively poor on Caucasians and blacks.

The third disadvantage is that during the treatment period, there is a certain probability of immune stress response, which may lead to severe allergies.

Therefore, before this drug is used, it must undergo relevant genetic testing, just like allopurinol. Patients with several specific allergy gene targets cannot use this drug.

Fortunately, those specific allergy gene targets are more common in Caucasians, and the carrier rate in Caucasians is about 20% to 30%; the probability of Asians carrying this gene is about 4%.

This is the exact opposite of allopurinol. In fact, this situation did not occur because the Hailufeng laboratory did it intentionally, but because the human gene database used by the laboratory was mainly based on the domestic population.

This is also a problem that many gene-targeted drugs cannot avoid.

That is, the gene targets of many gene-targeted drugs are often the common genes in the drug’s place of origin, which certainly cannot cover all ethnic groups in the world.

“What are the circumstances of these relapse cases?”

Hearing this question, Zhang Suqing replied helplessly: “Boss, you don’t know how much people in the coastal areas of Lingnan like to eat seafood. Many people start to eat a lot of meat and fish again after just a few months, and stay up late to drink beer. Especially during the Spring Festival, many patients eat too much high-protein, high-sugar, and high-fat food, coupled with excessive drinking, their bodies are once again in trouble.”

Jiang Miao sighed lightly: “Sure enough, eating habits are the core factor of gout. If you don’t change your eating habits, gout will come back sooner or later.”

Zhang Suqing shook his head: “Now many people have come back to participate in clinical trials. I am also overwhelmed by them.”

“Side effects…” Jiang Miao looked at the toxic and side effect research in the second half of the report.

The toxic side effects of Kangfengling are, on the one hand, allergies to specific genes. If you don’t have specific genes, you don’t need to worry about this problem.

On the other hand, it does cause certain damage to the liver. However, at the same daily dose, the damage caused by Kangfengling to the liver is slightly smaller than that of Febuxota, only about one-third.

Since the liver has strong self-repair capabilities, the problem is not that big.

After all, the presence of hepatotoxicity is a common feature of almost all drugs, and there is no way to avoid it because the liver is the main organ for metabolizing drugs.

Therefore, the drugs currently on the market are either hepatotoxic, nephrotoxic, or both.

The key is the dosage of the drug.

If the dosage is properly controlled, the medicine is a good thing that saves lives; if the dosage is used improperly, the medicine may become an accomplice to murder.

After reading the clinical test report of Kangfengling, Jiang Miao turned to another clinical test report, which was about the clinical test report on the treatment of Alzheimer’s disease.

“Alzheimer’s?”

Zhang Suqing recalled: “This project? This is the result of the 124 laboratory. The results of this project are currently being tested and are performing well.”

Jiang Miao looked at the descriptions page by page and quickly figured out the treatment plan of Laboratory 124.

The treatment plan of the 124 laboratory is not to restore memory. Instead, it uses nanoneedles to directly inject specific drugs into the brain. These drugs are gene-targeted drugs that can repair some brain nerve endings. Then, various electrical stimulations are performed through silver-coated nanotubes to reactivate some of the degenerated neurons in the brain.

The treatment only needs to last one to three months and the patient’s brain will return to normal, but the consequence is that some memory will be lost and memory reconstruction will be required. The advantage is that mental disorder and memory confusion will not occur.

Jiang Miao has already understood the team’s thinking, which is that function is important, not memory. As long as the brain function is restored, the memory can be reconstructed. If the brain function cannot be restored, there is no point in retaining the memory.

In fact, there is no way around this.

Because Alzheimer’s disease is essentially a degeneration of brain function, and this degeneration manifests itself as confusion in the reading of memory by brain cells.

Why do Alzheimer’s patients often have very clear memories of their youth, but have vague memories of their later years, or even directly forget the relevant memories of their later years?

The answer lies in the memory function of brain cells, which has the characteristic of time solidification. The older the memory, the more unforgettable the memory, the stronger the memory structure in the brain cells. The more recent the memory, the easier it is to forget.

After the function of brain cells degenerates, some structures forming shallow memories begin to be destroyed, making them unreadable or incompletely readable.

Those deep memory structures are better preserved because of their solidity.

Therefore, researchers from Laboratory 124 used the Nuwa system to investigate various genes related to the human brain, and finally found a number of related gene targets.

In a series of animal experiments, they subjected the brains of animals that had received targeted drug treatment to specific electrical stimulation and found that they could restore normal brain function, but the side effect was that some shallow memories would be lost.

A researcher in the laboratory was conducting research in this area in order to find a treatment for his father’s Alzheimer’s disease, so he arranged for his father to participate in the clinical trial.

The researcher’s father became the first patient to receive the treatment.

The treatment was very effective. Although the patient had lost a lot of memories from the past decade or so, after more than three months of memory reconstruction, he was able to resume his normal life. At least he would not get lost, mistake people, or run around.

After that, 8 more clinical tests were carried out one after another. Those patients who happened to have relevant targets after genetic testing all received relatively good treatment.

One of the patients, who had been ill for less than half a year, had only lost about one year’s worth of memory.

As Alzheimer’s disease progresses, brain function deteriorates more and more, and memory loss naturally increases. Therefore, the longer you wait, the more memory you lose.

Currently, 100 Alzheimer’s patients have signed up to participate in the third phase of clinical trials.

Obviously, for the vast majority of Alzheimer’s patients, memory is really not important, especially for their families. What they want is for the patients to regain the ability to take care of themselves, rather than becoming a huge burden on the family.

It doesn’t matter how many years of memory are lost.

You know, caring for Alzheimer’s patients is a very troublesome thing, mainly because these patients are gradually losing their self-awareness and their various behaviors become uncontrollable.

Jiang Miao was optimistic about this project, so he looked up and said, “Since there are so many successful cases for this treatment plan, let’s expand the scope of clinical testing!”

“Okay, boss, I will communicate with the technology department.” Zhang Suqing also knew that this was the general trend.

The subsequent clinical test reports seemed to be mediocre. Although there were certain successes, they were all small innovations. Compared with the previous gout cure and Alzheimer’s disease treatment technology, they were not on the same level.

Of course, Jiang Miao did not belittle these projects. After all, this is also the result of the efforts of many scientific researchers. The science and technology division will conduct internal assessments of these achievements based on their commercial, social and strategic nature, and then provide incentives to relevant scientific research teams.

Just at this moment, a phone call came in. Jiang Miao looked at the number and immediately went to the small room in the conference room to answer it.

“Hey…”

After a while, Jiang Miao came out with a frown on his face: “Youwei, Suqing, we’ll stop here today. I have something urgent to deal with.”

“Goodbye, boss.” Zhang Suqing hurried to open the door.

“Teacher, go and do your work! There’s nothing important happening here.” He Youwei knew that Jiang Miao would not suddenly change his schedule unless there was something very important.

“Yeah.” Jiang Miao didn’t say anything polite and hurriedly left the Hailufeng Hospital in the urban area with Ke Yong, Li Zixuan and others.

His security convoy did not return to the company headquarters, but instead drove towards the high-speed railway station.

(End of this chapter)