Chapter 252: Using your own medicine to treat the side effects of your own medicine! (5K)

“Hey, Xiao Liu, have you heard that all the combined drug treatments in the isolated critical care test area have been stopped? It is said that only ‘ibumaxomubac’ will be used for treatment in the future, and the ‘allogeneic T cells’ will no longer be injected!”

“Ah?! Sister Li, I don’t know. What’s wrong? They are using it very well. They all say that the treatment effect is good!”

“Well, what else can we do? It is said that there are serious side effects. One patient’s bone marrow stem cells have failed!”

“Bone marrow stem cell failure?! Are there really side effects?!”

“Oh, yes, it seems that Director Hu and Qingshan Pharmaceutical did not deceive us before, the combined treatment plan really has strong side effects!

It’s just… I feel even worse now. I actually hope that Qingshan Pharmaceutical really wants to make more money by not giving us the drug. This is better than the combined treatment program being stopped because of the side effects!
If there is no combination therapy, what will happen to us leukemia patients? “

“Hey……”

After a brief discussion between Zhang Yang, Wei Tian and Dr. Zhou, they immediately stopped the clinical trial of the combined treatment of “ibukumab” + “allogeneic T cells”.

On the one hand, Zhang Yang has realized the seriousness of this side effect.

On the other hand, this is also the regulation of clinical trials.

Once a clinical trial causes irreversible damage to vital organs of the human body, the clinical trial company must stop the clinical trial immediately.

It will not be possible to restart clinical trials until a solution to the side effects is found, or after comprehensive evaluation, it is considered that the probability of such side effects is extremely small!
Such a move certainly attracted the attention of all the subjects, and the news of serious side effects of “ibukumab” combination therapy spread like wildfire.

However, compared with the private discussions and concerns of ordinary subjects, Director Hu and Wei Tian found it difficult to face Liu Xiaochuan, who was in bed 79 and had side effects.

“Liu Xiaochuan, this is probably the situation.”

“Unfortunately, in the latest bone marrow puncture, we found that your bone marrow stem cells were failing, and it has been confirmed that you have functional failure of bone marrow stem cells.”

“According to our judgment, this should be the side effect caused by the long-term activation of the human body’s acute immune response by ‘allogeneic T cells’. I’m sorry…”

When Director Hu and Wei Tian came to his ward in person with serious faces, Liu Xiaochuan noticed something unusual.

But after hearing Director Hu say that he had the side effects of bone marrow failure, his mood couldn’t help but fall to the bottom.

Why me again?

“So, Director Hu, the reason why everyone stopped the combined treatment plan this time was because I had side effects?”

“Ok!”

Director Hu nodded heavily without hiding anything.

“All right!”

After the shock, perhaps because he had experienced too much, Liu Xiaochuan exhaled heavily and his face became calm.

He even showed a faint smile:

“Director Hu, and President Wei, you two don’t have to blame yourselves.”

“After all, you informed me of the possible risks of side effects when conducting the clinical trial. I am also a reasonable person. I will not blame you, nor will I cause you any trouble.”

Director Hu nodded slightly and let out a breath.

In his decades of medical practice, he has seen too many unreasonable patients and many reasonable patients.

After a moment, he continued:

“thank you for understanding.”

“However, I came here with President Wei today, in addition to telling you about the side effects, there is another thing.”

“Although you did have ‘bone marrow stem cell failure’ in your body, we have also thought of another solution.”

“We want to give you an injection of ‘ITG human myelopoietin’ to see if it can reverse the depletion of your bone marrow stem cells.”

“Because although Qingshan Pharmaceutical’s ‘ITG human myelopoietin’ is used to treat aplastic anemia, the essence of ‘plastic anemia’ is actually the failure and abnormality of bone marrow stem cells, so this can also be considered a symptomatic treatment!”

Liu Xiaochuan was stunned, and immediately said excitedly:

“Yes, yes, yes! I know ‘ITG human bone marrow’. It is used to treat abnormal bone marrow function! It will definitely work!”

“Director Hu, I do, I do!”

……

After obtaining Liu Xiaochuan’s consent, Tsingshan Pharmaceutical immediately began to treat Liu Xiaochuan’s side effects of “bone marrow stem cell functional failure”.

To be honest, Zhang Yang, Director Hu, and no one else knew whether it would be effective or not, so they could only give it a try.

Precisely because of this uncertainty, Tsingshan Pharmaceutical did not disclose the “ITG myelopoietin” treatment plan, and even reminded Liu Xiaochuan to try not to leak it.

Of course Liu Xiaochuan agreed readily.

Soon, a 10-ml injection of “ITG human myelopoietin”, which has been on the market for more than seven years by Qingshan Pharmaceutical, was injected into Liu Xiaochuan’s body.

A week later, Liu Xiaochuan’s first blood test results came out.

The blood count results were not very good, with red blood cells, white blood cells and red blood cells still below the normal range.

Director Hu was not too anxious.

His many years of experience in using “ITG human myelopoietin” told him that the effect of ITG will only be seen after at least four injections.

However, Director Hu was not in a hurry. The remaining 31 critically ill patients were anxious after the combined treatment was discontinued for a week.

“Director Hu, can you please not stop our combined treatment plan? I’ve only stopped taking the medicine for a week and my leukemia cell percentage has increased again! I’m so anxious!”

“Yes, Director! The combined treatment I used for more than half a month before was the best treatment effect since I was diagnosed with leukemia! The cancer cells in my body could not even be detected! The complications also disappeared. After stopping for a week, all the symptoms returned!”

“Hey! Director, we are really dying. Can you tell Qingshan Pharmaceutical that I understand you are worried about side effects, but didn’t we sign an informed consent form? I will accept side effects even if they occur! Isn’t it just bone marrow failure? It’s better than being tortured to death by leukemia, right?”

“Yes, bone marrow failure is better than leukemia metastasis, right? Besides! Even if there are side effects, not everyone will experience them!”

“Director Hu, is there any other solution now? We really want to use a combined treatment plan!”

Listening to the patients’ complaints and inquiries, Director Hu was quite helpless. He could only say that Qingshan Pharmaceutical was already taking action.

Not only domestic patients are paying close attention to the side effects of “Ivacuzumab” combination therapy, but foreign leukemia patients are also paying close attention to it!

To know,
Tsingshan Pharmaceutical’s “Ivacuzumab” combination treatment plan has just been released and has been dubbed the “miracle drug for acute leukemia” with a basic treatment efficiency of 83%. It has been wildly spread on overseas social media such as Titok and Facebook, bringing hope to countless overseas leukemia patients and families!
In order to learn the latest situation, many overseas patients even used translation software to download Chinese apps such as Weibo and Xiaohongshu, and then sent the information they learned back to China.

It can be said,
For a time, the combined treatment plan of “ibukumab” + “allogeneic T cells” was suspended, which worried countless leukemia patients.

Director Hu and Zhang Yang knew about this situation, but everything had to wait for the treatment results of “ITG human myelopoietin”.

but……

Just two weeks after the injection of “ITG human myelopoietin”, an exciting good news suddenly appeared on Director Hu’s desk!
“Fuck! Liu Xiaochuan’s blood index didn’t even improve last week, but he recovered completely in just one week?!”

“Also, the bone marrow smear is normal!”

“So fast! ITG is a miracle drug!”

Director Hu swore for once. According to his many years of clinical experience, “ITG myelopoietin” should show obvious effects in the fourth week, but he didn’t expect it to happen so soon!

However, he was too lazy to think about the specific reasons, and quickly called Zhang Yang to tell him the news.

“Mr. Zhang, it’s done, it’s done!”

“The results just came out. In just two weeks, Liu Xiaochuan’s bone marrow hematopoietic stem cells have returned to normal!”

“ITG myelopoietin can really treat the side effects of bone marrow failure caused by ‘allogeneic T cells’!”

“what!”

Zhang Yang on the other end of the phone was also extremely surprised.

He thought that “ITG myelopoietin” might be able to treat bone marrow stem cell failure, but he didn’t expect it to happen so quickly.

“The simulator’s drugs are awesome!”

“ITG myelopoietin has been developed into a new use seven years after it was launched on the market. It has become a part of the treatment for leukemia!” “It’s ridiculously strong!”

As he said this, he breathed a sigh of relief!
“Director Hu, don’t get excited. I’ll come to the hospital right away. I want to see the treatment effect with my own eyes!”

“Okay, I’ll wait for you!”

……

The solution to the side effects caused by “allogeneic T cells” means that all obstacles to the “ibumaxin” combination therapy have been removed.

It also means that the top leukemia treatment program with a basic treatment rate of 83% will start clinical trials again.

In the Qingshan Pharmaceutical Drug Research and Development Center, the haze that had lingered in everyone’s hearts for half a month was finally swept away.

Wei Tian sat at the conference table, very excited.

“Mr. Zhang, I didn’t expect that we would have to rely on the drug we developed seven years ago. ITG myelopoietin is really ‘old and strong’.”

“Ha ha!”

Everyone in the conference room laughed.

In fact, after so many years of clinical use, drugs like “ITG” have almost been explored for their basic clinical uses. I never expected that they could be expanded to new uses here.

“Boss, then our plan for treating leukemia can basically be determined.”

“Patients can be treated with a combination of ‘Ivolumab’ + ‘allogeneic T cells’. It would be best if there are no side effects. If side effects occur, we can inject our ‘ITG myelopoietin’ to treat the side effects caused by ‘Ivolumab’!”

“Yes! That’s the logic.”

Zhang Yang nodded, but soon, not only he, but everyone at the meeting discovered a very subtle problem.

The speaker was Ren Xiaomin, who came to listen after learning that there had been major progress in “Ibetuzumab”.

He couldn’t help but frowned slightly:
“Zhang Yang, from a medical perspective, I fully agree with the logic you just stated.”

“but……”

“Emotionally, it just feels weird to me, using our medication to treat side effects caused by our medication??!”

“If I tell this to others, I feel like I’ll be led by others!!”

“Is this two medicines for one disease?”

Zhang Yang also realized this problem at this time.

It would be fine if “ITG human myelopoietin” was a drug from another pharmaceutical company, but it is exclusively produced and sold by Qingshan Pharmaceutical, which makes it hard not to make mixed associations!
finally.

After thinking for a long time, Zhang Yang smiled bitterly. He had no good way to solve this problem!
“Forget it, we have a clear conscience!”

“Let others think whatever they want and say whatever they want!”

“All right!”

Seeing this, everyone stopped talking:
“Boss, I will report the treatment results to the Ethics Committee and apply to restart the combined treatment plan of ‘Ibetumumab’!”

“According to Director Hu, many seriously ill patients in the hospital can’t wait any longer, and their physical conditions have indeed rebounded!”

“it is good!”

Wei Tian quickly took action, but on the other side of the ocean, Pfizer was still immersed in the excitement of the suspension of the clinical trial of “Ibetumumab”.

In the president’s office, Daniel looked at Mike, the head of the technical research and development department, with a smile on his face.

“Mike, you are absolutely right. There is indeed a problem with Qingshan Pharmaceutical’s ‘Ibeumab’ combined with ‘allogeneic T cells’!”

“And I just got some new news from them. They are helpless against the side effects and are in a state of panic!”

“Haha, this feels so good!”

Mike looked at the excited president and smiled:
“Mr. President, I have said before that ‘allogeneic T cells’ are mainly used in CAR-T cell therapy. We have done in-depth research on ‘allogeneic T cells’, including side effects!”

“To paraphrase Trump, no one knows more about ‘allogeneic T cells’ than me!”

“Haha! Mike, I didn’t realize you were so humorous before. Come on, cheers! Cheers to us for causing a little trouble for Qingshan Pharmaceutical!”

“cheers.”

Although the two of them didn’t have red wine glasses, there were two cups of freshly brewed coffee on the coffee table.

With a light touch, Daniel took a sip of coffee with a smile on his face and said:
“Tsingshan Pharmaceutical’s ‘Ibetumumab’ was previously touted worldwide as a miracle drug for treating ‘acute leukemia’, but now they have no choice but to stop clinical trials!”

“Mike, how is the progress of our leukemia drug project? Can we catch up with Qingshan Pharmaceutical’s progress this time?”

Hearing Daniel talking about the drug that his company was developing, which also treats acute leukemia, Mike gently put down his coffee cup and said confidently:
“Of course, President, don’t worry. We have made new progress in our latest leukemia drug… I have to say that Qingshan Pharmaceutical’s ‘Ibetumumab’ has also provided us with a lot of ideas. We will be able to conduct clinical trials soon!”

“Oh fine!”

Daniel’s originally very good mood suddenly turned cold for no reason.

Perhaps it was the sentence “Qingshan Pharmaceutical’s ‘Ibeumab’ also provided us with a lot of ideas” that stimulated him. He did not continue to speak, but paused for a few seconds before slowly saying:

“Mike, let’s get back to talking about Qingshan Pharmaceutical!”

“It seems that Qingshan Pharmaceutical is unable to solve the side effects of ‘allogeneic T cells’. Do you think they can solve this side effect?!”

“We have to admit that, aside from the side effects, Tsingshan Pharmaceutical’s ‘ibumaxin’ combination therapy is indeed very powerful!”

“If they were allowed to solve the side effect problem, Ibelumab would 100% become a huge hit in the field of acute leukemia, and all our leukemia drugs would be crushed and completely withdrawn from the market! This is something we cannot tolerate!”

Mike shook his head without hesitation:

“Mr. President, rest assured. I have carefully studied the core treatment plan of Qingshan Pharmaceutical’s ‘Ibeumab’. The core is to stimulate the body to produce acute rejection and thus increase a glycogen substance…”

“At present, ‘allogeneic T cells’ are the most mainstream solution. As long as their core treatment plan does not change, they cannot avoid the side effects of ‘allogeneic T cells’!”

“So, don’t worry, they can’t avoid the side effects of bone marrow failure at all!”

“All right!”

Daniel smiled brightly again and raised his glass again:
“Mike, it is a blessing for Pfizer to have top R&D talents like you…”

As he spoke, Daniel suddenly noticed that the screen of the iPhone 17 on the coffee table suddenly lit up.

Before he could react, a push message appeared on the screen.

This is an industry APP that specializes in reporting on medical research and development.

[Latest news: Qingshan Pharmaceutical has restarted the ‘Ibetumumab’ combination treatment program, and the leukemia miracle drug has started clinical trials again! ]

“impossible!”

Daniel put down his coffee cup suddenly and quickly opened the APP message.

After a full minute, he looked at Mike with shock on his face and anger in his eyes!
“Fuck!”

“Mike, you are right. Qingshan Pharmaceutical has no way to avoid the side effects of ‘allogeneic T cells’, and has never thought about circumventing the side effects!”

“They actually used ‘ITG human myelopoietin’ directly to treat the side effects!”

“It’s cured!”

“Fuck! How could they come up with such a plan!”

Mike was confused and quickly took the phone from Daniel. He was furious when he saw it.

“ITG human myelopoietin?!”

“They actually used their own medicine to treat the side effects caused by their own medicine?!”

“Shameless!”

(End of this chapter)