Chapter 249 The effect of combined medication is released! Qingshan Pharmaceutical is awesome! (Please give me a monthly ticket!)
“Bed 79, Liu Xiaochuan, after four weeks of clinical treatment, your acute leukemia can be said to be under relatively good control.”

“According to the results of the latest peripheral blood smear test yesterday, the proportion of leukemia cells in your peripheral blood is still controlled at about 27%. That is to say, compared to when you were first admitted to the hospital, about 73% of the leukemia cells have been effectively killed.”

“This treatment effect is above average among all the subjects. If the patient is treated with long-term injections of ‘ibumabucil’, he may be able to survive for a longer period of time, but…”

“After a period of research and improvement on Ibelumab by Qingshan Pharmaceutical, they have customized a new combination therapy plan, which may have a better therapeutic effect. So I would like to ask if you are willing to modify the previous treatment plan and switch to the latest combination therapy.”

Combination therapy?

Although Liu Xiaochuan is only 24 years old, as a veteran patient, he certainly knows what combined treatment means.

But soon, his attention shifted away from the joint treatment, and he suddenly said excitedly: “”

“Director Hu, has the improvement plan that we fully supported Qingshan Pharmaceutical finally produced any results?”

“So, this combined treatment is actually the result of the previous improved plan?”

Director Hu smiled.

He was deeply impressed by Liu Xiaochuan, the patient who was the first to stand up and express support for Qingshan Pharmaceutical’s improvement plan in the ward.

Nodding, he did not hide anything:

“Yes, this combined treatment plan is the latest plan developed after the improvement plan research that you supported before.”

“Why hesitate? I’m definitely willing to participate!”

Director Hu’s smile widened. He could clearly feel the trust and expectations of the patient in front of him.

After a moment, he shook his head and said:
“I still have to explain it to you in detail.”

“As you know, when we were conducting clinical trials before, we stopped all the drugs and only injected Ibetumumab once a week for treatment.”

“But in addition to using ‘ibumaxomubicin’, this combined treatment will also include a drug called ‘allogeneic T cells’!”

“This ‘allogeneic T cell’ is mainly to activate your body’s immune system, thereby increasing the metabolic rate of your immune cells;

I won’t explain the specific treatment principle in detail. In short, the ultimate purpose of using this drug is to enhance the therapeutic effect of Ibelumab! ”

When Liu Xiaochuan heard that it was about enhancing the therapeutic effect of “Ibetuzumab”, he was stunned and suddenly wanted to speak excitedly.

Director Hu waved his hand again and interrupted with a smile:
“Don’t be in a hurry to speak, just listen to me finish everything first.”

“Of course, ‘allogeneic T cells’ are an immune drug, and there is a high probability of multiple side effects after injection.”

“Common symptoms include fever, immune dysfunction, endocrine disorders, etc. The most serious cases may even lead to organ failure in the body due to long-term acute rejection, such as the failure of normal bone marrow hematopoietic stem cells in your body!”

“This is a side effect you must be aware of!”

Director Hu spoke the last few sentences with a serious expression, and Liu Xiaochuan was also slightly stunned.

But soon a smile appeared on his face, showing his white teeth:
“Director Hu, I know, but I’m not afraid; or I don’t have the capital to be afraid of any side effects now!
“I don’t even remember how many times I’ve had chemotherapy before. As long as the leukemia cells in my body can be controlled and I can live a few years normally, I’m willing to do anything!”

Director Hu smiled silently and then nodded.

“Well, since you have no concerns, then sign the informed consent form and we will switch to combined treatment tomorrow at the latest.”

“Okay!”

……

Liu Xiaochuan was the first patient that Director Hu personally met. Soon after, Zhang Lele, who was only eight years old, and his father also came to Director Hu’s office.

“Lele’s father, Lele is in good condition now… Qingshan Pharmaceutical has recently developed a new combined treatment plan…”

“Director Hu, we have already understood the side effects clearly. We are willing to do so!”

“it is good!”

……

“Xia Xue…”

“Director Hu, I won’t say any more. I’ll just sign it. Like I said before, I accept all the proposals from Qingshan Pharmaceutical. I’m still waiting for them to develop a drug that can completely cure leukemia!”

……

The combined treatment regimen using “allogeneic T cells” progressed exceptionally smoothly, especially when they learned that this combined regimen was the result of the previous improvement plan. Almost all of the 32 patients accepted the new combined treatment regimen without hesitation.

joke,

In the words of many patients, they have to “enjoy” the pain they suffered in the previous improvement plan.

As for the side effects, people don’t seem to take them too seriously.

of course,

Director Hu knew that almost all patients knew that they had a “terminal illness” and were on the verge of death, so why would they care about any side effects?

Secondly.

Director Hu also knows that this is everyone’s trust in Qingshan Pharmaceutical.

Two days later, everything was arranged.

Thirty-two patients who received independent treatment were switched to combination treatment at week 5 after completing four weeks of treatment with “ibukumab” alone.

As the imported “allogeneic T cell” injections were injected into the bodies of 32 patients, the first project team of Qingshan Pharmaceutical immediately started blood tests on the 32 patients.

The first step is to detect whether an “acute rejection reaction” has occurred in the patient’s body, causing an increase in the metabolic rate of immune cells.

The second step is to detect whether the TEF glycoprotein concentration in the patient’s body is increased.

We must briefly talk about the “allogeneic T cell” injection here.

“Allogeneic T cells” are a new type of immune preparation that has only appeared in recent years. They are mainly used in a new type of treatment method – CAR-T cell therapy!

Simply put, the treatment principle is to implant “allogeneic T cells” into the patient’s body to activate the human immune system, and then kill tumor cells through the body’s own immune cells!
Correct,
“Allogeneic T cells” are actually also a type of immune drug used to treat cancer, but the technology is not yet mature enough.

Therefore, the “allogeneic T cells” that Tsingshan Pharmaceutical directly used on 32 patients were all drugs that had completed clinical trials and were approved for marketing, so they could be used directly for treatment.

soon.

Six hours after the “allogeneic T cell” injection, Qingshan Pharmaceutical collected blood samples from 32 subjects for the first time.

“Mr. Zhang, after the ‘allogeneic T cell’ injection was injected into the human body, an immune response occurred as per the drug instructions. The patient’s immune cells, especially T cells, began to proliferate in large numbers and their metabolic rate began to increase!”

“Several patients have developed a low-grade fever of 37.1, and there is a high possibility that they are beginning to have an acute rejection reaction!”

“And the TEF glycoprotein concentration…also increased slightly!”

Zhang Yang exhaled lightly.

“Keep monitoring!”

“Ok.”

Twelve hours later.

“Mr. Zhang, 19 out of the 32 patients have developed a low-grade fever, and it has been confirmed that they have an ‘acute rejection reaction’ in their bodies.”

“The metabolic rate of immune cells in all patients increased to 0.3mmol/min, nearly twice that of normal people!”

“As for TEF glycoprotein…the concentration in the blood of 32 patients has increased significantly, and in some patients, the concentration has almost doubled compared to before!”

“Do you think we should give the patient an injection of ‘ibuzumab’ now?”

Zhang Yang thought for a moment and shook his head.

“hold on.”

Twenty-four hours later.

“Mr. Zhang, among the thirty-two patients, twenty-nine of them have developed low-grade fever symptoms. It has been confirmed that an ‘acute rejection reaction’ has occurred in their bodies.”

“At the same time, after one night, the metabolic rate of immune cells in all patients increased to three times the normal value!”

“As for TEF, even the patient with the lowest TEF glycoprotein in his body before has now basically reached Xia Xue’s level!”

Hearing this, Zhang Yang handed the experimental data in his hand to Dr. Zhou and Wei Tian.

When the two people’s eyes lit up, he nodded and said:
“The timing is almost right. All patients have enough TEF concentration in their bodies!”

“Go ahead and tell Director Hu that all patients can be injected with ‘ibumaxin’. The combination drug therapy is now officially complete!” “Okay.”

three days later.

Inpatient Department of Hematology, Chengdu Third People’s Hospital.

Ward No. 40.

“Le Le, today is the fourth day of the ‘ibumaxin’ combination therapy. It is also the day when Qingshan Pharmaceutical will tell us the treatment results. Are you nervous?”

Zhang Lele, who was only eight years old, shook his head as he lay alone on the hospital bed playing with his mobile phone.

His father went to the hospital cafeteria to buy him food, leaving Zhang Lele and Liu Xiaochuan alone in the ward.

“Brother Xiaochuan, I’m not nervous. I feel my body is getting better and better!”

“Dad said we can go home in two months after we complete the clinical trial!”

“What’s wrong? Are you nervous?”

“Ok!”

Liu Xiaochuan nodded heavily.

“Brother is very nervous now!”

“I don’t believe it. Dad once said that you are very brave and a real man. He wanted me to learn from you!”

“Ha ha!”

Liu Xiaochuan was slightly stunned, then shook his head with a wry smile.

That’s right, he had no concerns when he participated in the “Ibetumumab” improvement plan before, but now…

After actually accepting Qingshan Pharmaceutical’s latest combination medication, I couldn’t help but feel nervous.

After a moment, he took a deep breath and continued:

“By the way, Lele, is your mild fever better? Do you still have a fever today?”

“No, I didn’t have a fever when I took my temperature this morning. But I heard from my father that a low-grade fever is actually a good thing. He said that some immune cells have been mobilized… What about you? Brother Xiaochuan!”

“I don’t have a low-grade fever anymore…”

Liu Xiaochuan’s tense mood eased a little, but at this moment, a nurse suddenly walked into the ward.

Liu Xiaochuan glanced at him from the corner of his eye and instantly became nervous again.

“Bed 79, Liu Xiaochuan, your latest peripheral blood smear results…”

“And there’s Zhang Lele in bed 78. Your father isn’t here, right? Check your results and I’ll show them to your father later!”

Liu Xiaochuan took the examination report handed over by the nurse with slight trembling, and his eyes instantly fell on the most important indicator!

“Percentage of peripheral blood leukemia cells: 13%.”

13%!

He was shocked, then ecstatic!

Doesn’t a ratio of 13% mean that 87% of the leukemia cells in the body have been killed?
He remembered that his last test result was 73%!

Improved by 14%!

The combined use of drugs really improves the effect!
“Brother Xiaochuan, is your treatment more effective? Can you help me take a look?”

Lele, who was lying on the hospital bed, no longer played with his mobile phone and looked at Liu Xiaochuan with anticipation.

Liu Xiaochuan hurriedly took over Zhang Lele’s examination report and was instantly even more shocked!

“LeLe, I remember your treatment effect was only… 65%, right?”

“My God, your combination drug is more effective than mine this time. The proportion of leukemia cells in your body is only 11%!”

“That means your treatment effect has reached 89%! An improvement of 24%!”

“too strong!”

“Brother Xiaochuan, can I go back to school?”

“Yes, of course! If you can achieve this effect in the long term, you can go back to school!”

“Oh yeah, I can read! I can read!”

……

As the nurse handed out 32 test results to the patients, the entire hematology department burst into cheers.

Qingshan Pharmaceutical, Zhang Yang’s office.

“Mr. Zhang, good news! The medication results of the 32 independent subjects are all out!”

“The treatment effects of the thirty-two patients have all improved, especially in terms of stability. Previously, the worst treatment effect could only reach 51%, but now!”

“After combined use of the drug, even the patients with the worst treatment effect achieved an 82% kill rate, and 80% of the patients directly achieved a treatment effect of more than 86%!”

“It can be said that the effect of ‘ibukumab’ in treating acute myeloid leukemia has completely met our expectations!”

Hear Wei Tian report excitedly!
Even though Zhang Yang had expected this, he couldn’t help but let out a long sigh of relief at this moment!

The plan to improve the stability of “Ibetumumab” treatment has finally been successful!

But soon, he thought of Xia Xue and felt a little excited.

“By the way, where is Xia Xue’s data?”

“Xia Xue’s treatment data previously reached 91%. How effective is this time after combining it with ‘heterogeneous T cells’?”

Wei Tian was obviously also concerned about Xia Xue, and answered quickly without hesitation:
“Xia Xue’s healing effect has also improved, but not much!”

“It has increased from 91% to 94%!”

Zhang Yang was stunned for a moment, then forced a bitter smile.

Wei Tian continued:

“Boss, I have also carefully analyzed the reason. Although the concentration of TEF protein in Xia Xue’s body has increased again, there should still be a small number of leukemia cells in her body that even TEF protein cannot recognize well.”

“so……”

Please sighed and said:

“However, I think her condition is already very good. If she doesn’t develop drug resistance, it won’t be a problem for her to live for another 20 to 30 years with such a low viral load!”

“I’m afraid leukemia will have been conquered in 20 or 30 years!”

Zhang Yang nodded and regained his composure.

Indeed, this result is very satisfying!

“Wei Tian, ​​you are right, there is really no need for us to be so picky!”

“Ok!”

Wei Tian smiled, and after a moment of hesitation, he said:

“Boss, now that our latest clinical trial results are out, should I announce them to the public right now?”

Zhang Yang did not hesitate!

“Please announce it, and let the world see our latest progress on ‘Ibetumumab’!”

“Great, 83% basic treatment effect! I wonder how shocking this data will be once it is sent out!”

Wei Tian was right. After the effect of the latest combination drug of Ibeumab from Qingshan Pharmaceutical was published on the official website of the evaluation center,

The entire leukemia patient community was devastated.

However, the first to explode were unexpectedly the double-blind patients who were undergoing clinical trials!
(End of this chapter)